Valencia declared coach Albert Celades’ sacking, with Voro Gonzalez being located on the side’s interim charge.
Celades took over the reins at Mestalla in September, after Marcelino’s departure.
They failed to local rivals Villarreal on Sunday and have won just one of their four matches since the resumption of Spanish football in recent weeks.
They are presently placed eighth in La Liga and have given up the services of the 44-year-old.
“Valencia CF has informed Albert Celades with immediate effect of his withdrawal from his position as the first-team coach,” a club statement read.
“The club would like to publicly thank him for his work and dedication during his time at the club-a period in which we achieved qualification for the Champions League knockout stages and important victories on grounds where we had not previously won.”
“Since he took over as coach of the first team in a difficult time, the club also value his help and contribution and wish him every success in his future endeavors.”
“From Tuesday, Voro Gonzalez will provisionally take charge of the first team through to the end of this season.”